{"id":309,"date":"2020-03-23T11:15:27","date_gmt":"2020-03-23T14:15:27","guid":{"rendered":"https:\/\/www.blogs.unicamp.br\/covid-19\/?p=309"},"modified":"2020-03-23T11:15:27","modified_gmt":"2020-03-23T14:15:27","slug":"quimica-do-coronavirus-parte-ii","status":"publish","type":"post","link":"https:\/\/clorofreela.com.br\/revistablogs\/2020\/03\/23\/quimica-do-coronavirus-parte-ii\/","title":{"rendered":"Qu\u00edmica do Coronav\u00edrus – Parte II"},"content":{"rendered":"\t\t
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Prote\u00edna spike - presente de grego<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A prote\u00edna spike da SARS-CoV-2 \u00e9 a respons\u00e1vel pela nome caracter\u00edstico do v\u00edrus tal como vimos na postagem \u201cQu\u00edmica do Coronav\u00edrus \u2013 parte I\u201d<\/strong>, por causa do sua forma similar a de uma coroa. De forma bem resumida, a prote\u00edna spike do coronav\u00edrus \u00e9 uma m\u00e1quina molecular multifuncional que medeia a entrada de coronav\u00edrus nas c\u00e9lulas hospedeiras. <\/span>Dessa forma, os mecanismo de entrada na c\u00e9lulas s\u00e3o orquestrados por essa prote\u00edna que tem a capacidade de ligar-se aos receptores celulares e, tamb\u00e9m mediam as fus\u00f5es da membrana c\u00e9lula-v\u00edrus.<\/span><\/p>\n

Entre todas as prote\u00ednas estruturais do SARS-CoV, a prote\u00edna spike \u00e9 o principal componente antig\u00eanico respons\u00e1vel por induzir respostas imunes do hospedeiro, neutralizar anticorpos e\/ou imunidade protetora contra a infec\u00e7\u00e3o pelo v\u00edrus. Portanto, a prote\u00edna spike da SARS-CoV tem pap\u00e9is fundamentais na infec\u00e7\u00e3o viral e patog\u00eanese. <\/span>Na sequ\u00eancia, um v\u00eddeo  ilustrativo mostra como o v\u00edrus invade a c\u00e9lula ao ligar-se ao receptor que se encontra na superf\u00edcie da sua camada lip\u00eddica.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Uma vez ligado ao receptor celular, o v\u00edrus entra na celula na forma reconhecido e, portanto, protegido pelo sistema imunol\u00f3gico no interior da c\u00e9lula humana. \u00c9 como se fosse um presente de grego. O receptor n\u00e3o entendeu que abriu a porta e colocou para dentro da c\u00e9lula um invasor.<\/span><\/p>

Agora, dentro da celular, o v\u00edrus \u00e9 livre para se replicar e liberar novas c\u00e9lulas COV-2 totalmente funcionais que repetem exponencialmente o ciclo. A estrat\u00e9gia mais comum adotada pelos pesquisadores \u00e9 um ativo qu\u00edmico que possa interromper essa entrada celular e, dessa forma neutralizar o v\u00edrus, deixando-o acess\u00edvel e vulner\u00e1vel ao sistema imunol\u00f3gico humano. Portanto, a ideia geral no desenvolvimento de f\u00e1rmaco direcionado ao COVID-2019 \u00e9 impedir a a\u00e7\u00e3o dessa importante prote\u00edna viral.[1]<\/a><\/p>

Para que a estrat\u00e9gia de impedir a entrada do v\u00edrus dentro da c\u00e9lula tenha sucesso faz-se necess\u00e1rio conhecer as estruturas da prote\u00edna Spike e dos receptores. \u00c9 a magnitude das intera\u00e7\u00f5es qu\u00edmicas que ocorrem entre as partes envolvidas do receptor celular e do coronav\u00edrus que ditar\u00e3o o sucesso dessa jornada na busca de novos medicamentos.Nesse contexto, a estrutura da glicoprote\u00edna spike (S) de SARS-CoV-2 revela a arquitetura do principal agente de entrada viral nas c\u00e9lulas hospedeiras, ao mesmo tem que fornece o desenho do futuro f\u00e1rmaco.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Refer\u00eancia bibliogr\u00e1fica<\/b><\/p>

[1]<\/span><\/span><\/a>\u00a0<\/span>Walls, Alexandra C, Young-Jun Park, M Alejandra Tortorici, Abigail Wall, Andrew T. McGuire, and David Veesler. \u201cStructure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.\u201d\u00a0<\/span>Cell<\/em>, 2020. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867420302622<\/a><\/span><\/p>

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Os argumentos expressos nos posts deste especial s\u00e3o dos pesquisadores, produzidos a partir de seus campos de pesquisa cient\u00edfica e atua\u00e7\u00e3o profissional e foi revisado por pares da mesma \u00e1rea t\u00e9cnica-cient\u00edfica da Unicamp.\nN\u00e3o, necessariamente, representam a vis\u00e3o da Unicamp. Essas opini\u00f5es n\u00e3o substituem conselhos m\u00e9dicos.\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\teditorial<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Prote\u00edna spike – presente de grego A prote\u00edna spike da SARS-CoV-2 \u00e9 a respons\u00e1vel pela nome caracter\u00edstico do v\u00edrus tal como vimos na postagem \u201cQu\u00edmica do Coronav\u00edrus \u2013 parte I\u201d, por causa do sua forma similar a de uma coroa.\u00a0De forma bem resumida, a prote\u00edna spike do coronav\u00edrus \u00e9 uma m\u00e1quina molecular multifuncional que medeia […]<\/p>\n","protected":false},"author":2,"featured_media":311,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[41,59],"tags":[342,346,356,358,1018],"class_list":["post-309","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-coronavirus","category-especial-covid","tag-corona","tag-coronavirus","tag-covid","tag-covid-19","tag-quimica"],"acf":[],"yoast_head":"\nQu\u00edmica do Coronav\u00edrus - Parte II - Revista Blogs Unicamp<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/clorofreela.com.br\/revistablogs\/2020\/03\/23\/quimica-do-coronavirus-parte-ii\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Qu\u00edmica do Coronav\u00edrus - 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